Medicine

Personal health reference — conditions, science, interventions, and day-to-day management. This vault is for understanding and living with specific conditions, not for building anything.

Mast Cell Activation Syndrome

Mast Cell Activation Syndrome/ — Deep reference on MCAS biology, triggers, interventions, and comorbidities.

Fundamentals

Mast cells, degranulation, IgE and non-IgE activation pathways, mediators (histamine, tryptase, leukotrienes, prostaglandins, cytokines, heparin), total mediator load.

Conditions and Comorbidities

• MCAS — The primary condition
• The Trifecta — MCAS, POTS, and EDS
• Histamine Intolerance vs MCAS
• Small Fiber Neuropathy, POTS, EDS
• ASD and Mast Cells

Dietary Triggers

• Dietary Histamine, Histamine Liberators
• Salicylates, Oxalates
• SIGHI Elimination Diet Protocol
• Fructans

Interventions

H1 and H2 antihistamines, mast cell stabilizers, ketotifen, montelukast, cromolyn sodium, DAO supplements, low dose naltrexone, GLP-1 receptor agonists.

Hormones, Nervous System, Gut

Estrogen/histamine feedback loop, HPA axis, sleep and histamine, gut-brain-mast cell axis, dysbiosis, histamine-producing and degrading bacteria, intestinal permeability, SCFAs and butyrate.

Diagnostics

Serum tryptase, 24-hour urine testing, chromogranin A, DAO serum levels, symptom mapping.

Living With It

• Living With Variable Reactivity
• Gastrocolic Reflex and Osmotic Dumping

Electrolyte Drink

Electrolyte Drink/ — MCAS-safe electrolyte formulation for daily use. Ingredient science, MCAS safety report, recipes, and flavor blends.

• How It Works — Science behind each ingredient
• Recipe, Recipe v2
• Flavor Blends, Shopping List
• MCAS Safety Report

Neurodivergence

Neurodivergence/ — Reference and management notes.

ADHD

Neurodivergence/ADHD/References/Borretti/ — Notes from Borretti’s ADHD management framework, covering chemistry, memory, energy, procrastination, time, task selection, visual field management, and workflow systems.

Maturity

Stage: Ongoing personal reference. This vault grows as conditions are researched and managed. It’s not a project — there’s nothing to build here. The MCAS section is extensive; the ADHD section is reference notes from a single source and will grow.